NR1D2 Antikörper (AA 14-318) (Biotin)

Produktnummer ABIN7161737

Produktdetails anti-NR1D2 Antikörper (Biotin)

Target: NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))

Bindungsspezifität: AA 14-318

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR1D2 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human NR1D2 protein (14-318AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NR1D2

Target: NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))

Andere Bezeichnung: NR1D2 (NR1D2 Produkte)

Synonyme: BD73 antikoerper, EAR-1R antikoerper, RVR antikoerper, HZF-2 antikoerper, Rev-erb antikoerper, REV-ERBB antikoerper, NR1D2 antikoerper, rvr antikoerper, bd73 antikoerper, hzf2 antikoerper, ear-1r antikoerper, hs.37288 antikoerper, NR1D2-A antikoerper, Reverbbeta-A antikoerper, reverbb1 antikoerper, reverbb antikoerper, reverbb2 antikoerper, zgc:92019 antikoerper, nuclear receptor subfamily 1 group D member 2 antikoerper, nuclear receptor subfamily 1, group D, member 2 antikoerper, nuclear receptor subfamily 1, group D, member 2a antikoerper, nuclear receptor subfamily 1, group D, member 2b antikoerper, NR1D2 antikoerper, Nr1d2 antikoerper, nr1d2 antikoerper, nr1d2a antikoerper, nr1d2b antikoerper

Hintergrund:

Background: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5\\\'-[A/G]GGTCA-3\\\' preceded by an A/T-rich 5\\\' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle.

Aliases: Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R), NR1D2

UniProt: Q6NSM0

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway