ZFP36 Antikörper (AA 16-103)
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- Target Alle ZFP36 Antikörper anzeigen
- ZFP36 (Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36))
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Bindungsspezifität
- AA 16-103
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ZFP36 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunofluorescence (IF)
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human mRNA decay activator protein ZFP36 protein (16-103AA)
- Isotyp
- IgG
- Top Product
- Discover our top product ZFP36 Primärantikörper
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- Applikationshinweise
- Recommended dilution: IF:1:50-1:200,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- ZFP36 (Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36))
- Andere Bezeichnung
- ZFP36 (ZFP36 Produkte)
- Synonyme
- G0S24 antikoerper, GOS24 antikoerper, NUP475 antikoerper, RNF162A antikoerper, TIS11 antikoerper, TTP antikoerper, zfp-36 antikoerper, c3h-1 antikoerper, g0s24 antikoerper, gos24 antikoerper, nup475 antikoerper, rnf162a antikoerper, tis11 antikoerper, ttp antikoerper, ZFP36 antikoerper, C3H-1 antikoerper, Gos24 antikoerper, Nup475 antikoerper, TIS11D antikoerper, TISII antikoerper, Tis11 antikoerper, Ttp antikoerper, Zfp-36 antikoerper, ZFP36 ring finger protein antikoerper, ZFP36 ring finger protein L homeolog antikoerper, tristetraproline antikoerper, Tristetraproline antikoerper, similar to Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth antikoerper, zinc finger protein 36 antikoerper, ZFP36 antikoerper, zfp36.L antikoerper, EDI_287240 antikoerper, Bm1_42085 antikoerper, LOAG_03119 antikoerper, zfp36 antikoerper, Zfp36 antikoerper
- Hintergrund
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Background: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:9703499, PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:27193233, PubMed:23644599, PubMed:25815583). Acts as an 3\\\'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3\\\'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:19188452, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses, suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Plays also a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism, assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping, enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077).
Aliases: G0/G1 switch regulatory protein 24 antibody, G0S24 antibody, GOS24 antibody, Growth factor-inducible nuclear protein NUP475 antibody, NUP475 antibody, Protein TIS11A antibody, RNF162A antibody, TIS 11 antibody, TIS11 antibody, TIS11A antibody, Tristetraprolin antibody, Tristetraproline antibody, TTP antibody, TTP_HUMAN antibody, Zfp-36 antibody, ZFP36 antibody, Zinc finger protein 36 antibody, Zinc finger protein 36 homolog antibody, Zinc finger protein 36, C3H type, homolog (mouse) antibody, Zinc finger protein, C3H type, 36 homolog antibody
- UniProt
- P26651
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