PRKRA Antikörper (AA 1-313)

Produktnummer ABIN7156699

Produktdetails anti-PRKRA Antikörper

Target: PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))

Bindungsspezifität: AA 1-313

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKRA Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Interferon-inducible double-stranded RNA-dependent protein kinase activator A protein (1-313AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PRKRA

Target: PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))

Andere Bezeichnung: PRKRA (PRKRA Produkte)

Synonyme: PRKRA antikoerper, AV120107 antikoerper, PRK antikoerper, Pact antikoerper, RAX antikoerper, lear antikoerper, DYT16 antikoerper, PACT antikoerper, im:7151758 antikoerper, zgc:162619 antikoerper, dyt16 antikoerper, pact antikoerper, prkra-a antikoerper, prkra-b antikoerper, rax antikoerper, rbpa antikoerper, protein activator of interferon induced protein kinase EIF2AK2 antikoerper, protein kinase, interferon inducible double stranded RNA dependent activator antikoerper, protein kinase, interferon-inducible double stranded RNA dependent activator antikoerper, protein activator of interferon induced protein kinase EIF2AK2 L homeolog antikoerper, PRKRA antikoerper, Prkra antikoerper, prkra antikoerper, prkra.L antikoerper

Hintergrund:

Background: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at \\\'Lys-386\\\' at \\\'Ser-392\\\' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

Aliases: DYT16 antibody, HSD14 antibody, Interferon inducible double stranded RNA dependent protein kinase activator A antibody, interferon-inducible double stranded RNA-dependent activator antibody, Interferon-inducible double stranded RNA-dependent protein kinase activator A antibody, PACT antibody, PKR associated protein X antibody, PKR associating protein X antibody, PKR-associated protein X antibody, PKR-associating protein X antibody, PRKRA antibody, PRKRA_HUMAN antibody, Protein activator of the interferon induced protein kinase antibody, Protein activator of the interferon-induced protein kinase antibody, Protein kinase antibody, Protein kinase interferon inducible double stranded RNA dependent activator antibody, RAX antibody

UniProt: O75569

Pathways: Regulatorische RNA Pathways