STT3B Antikörper (AA 682-809) (Biotin)

Produktnummer ABIN7150608

Produktdetails anti-STT3B Antikörper (Biotin)

Target: STT3B (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B))

Bindungsspezifität: AA 682-809

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STT3B Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B protein (682-809AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu STT3B

Target: STT3B (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B))

Andere Bezeichnung: STT3B (STT3B Produkte)

Synonyme: RGD1311563 antikoerper, 1300006C19Rik antikoerper, Simp antikoerper, SIMP antikoerper, STT3-B antikoerper, STT3B, catalytic subunit of the oligosaccharyltransferase complex antikoerper, STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) antikoerper, Stt3b antikoerper, STT3B antikoerper

Hintergrund:

Background: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR \'Asp-38\' of TTR at \'Asn-118\', leading to its degradation.

Aliases: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B antibody, Homolog of yeast STT3 antibody, Oligosaccharyl transferase subunit STT3B antibody, SIMP antibody, source of immunodominant MHC associated peptides antibody, Source of immunodominant MHC-associated peptides homolog antibody, STT3 subunit of the oligosaccharyltransferase complex homolog B (S. cerevisiae) antibody, STT3 subunit of the oligosaccharyltransferase complex homolog B antibody, STT3-B antibody, Stt3b antibody, STT3B_HUMAN antibody

UniProt: Q8TCJ2