CDK5RAP3 Antikörper (Regulatory Subunit) (Biotin)

Produktnummer ABIN7147235

Produktdetails anti-CDK5RAP3 Antikörper (Biotin)

Target: CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))

Bindungsspezifität: AA 42-292, Regulatory Subunit

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK5RAP3 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human CDK5 regulatory subunit-associated protein 3 protein (42-292AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CDK5RAP3

Target: CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))

Andere Bezeichnung: CDK5RAP3 (CDK5RAP3 Produkte)

Synonyme: cdkrap3 antikoerper, fb33h04 antikoerper, fc09c05 antikoerper, id:ibd2920 antikoerper, wu:fb33h04 antikoerper, wu:fc09c05 antikoerper, zgc:86863 antikoerper, CDK5RAP3 antikoerper, cdk5rap3 antikoerper, MGC82350 antikoerper, C53 antikoerper, HSF-27 antikoerper, IC53 antikoerper, LZAP antikoerper, MST016 antikoerper, OK/SW-cl.114 antikoerper, PP1553 antikoerper, 1810007E24Rik antikoerper, BC002318 antikoerper, C81486 antikoerper, CDK5 regulatory subunit associated protein 3 antikoerper, CDK5 regulatory subunit associated protein 3 L homeolog antikoerper, cdk5rap3 antikoerper, CDK5RAP3 antikoerper, cdk5rap3.L antikoerper, Cdk5rap3 antikoerper

Hintergrund:

Background: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).

Aliases: C53 antibody, CDK5 activator binding protein C53 antibody, CDK5 activator-binding protein C53 antibody, CDK5 regulatory subunit associated protein 3 antibody, CDK5 regulatory subunit-associated protein 3 antibody, Cdk5rap3 antibody, CK5P3_HUMAN antibody, HSF 27 antibody, HSF27 antibody, IC53 antibody, Ischemic heart CDK5 activator binding protein C53 antibody, LXXLL/leucine zipper containing ARFbinding protein antibody, LZAP antibody, MST016 antibody, OK/SW cl.114 antibody, PP1553 antibody, Protein HSF-27 antibody

UniProt: Q96JB5