MICAL2 Antikörper (AA 1-495)

Produktnummer ABIN7141994

Produktdetails anti-MICAL2 Antikörper

Target: MICAL2 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 2 (MICAL2))

Bindungsspezifität: AA 1-495

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MICAL2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human [F-actin]-monooxygenase MICAL2 protein (1-495AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MICAL2

Target: MICAL2 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 2 (MICAL2))

Andere Bezeichnung: MICAL2 (MICAL2 Produkte)

Synonyme: MICAL-2 antikoerper, MICAL2PV1 antikoerper, MICAL2PV2 antikoerper, 5330438E18Rik antikoerper, 9530064J02 antikoerper, mKIAA0750 antikoerper, RGD1311773 antikoerper, microtubule associated monooxygenase, calponin and LIM domain containing 2 antikoerper, MICAL2 antikoerper, Mical2 antikoerper

Hintergrund:

Background: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Aliases: MICAL2 antibody, KIAA0750 antibody, MICAL2PV1 antibody, MICAL2PV2 antibody, [F-actin]-monooxygenase MICAL2 antibody, EC 1.14.13.225 antibody, Molecule interacting with CasL protein 2 antibody, MICAL-2 antibody

UniProt: O94851