CENPA Antikörper

Produktnummer ABIN7139650

Produktdetails anti-CENPA Antikörper

Target: CENPA (Centromere Protein A (CENPA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CENPA Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Peptide sequence around site of Ser (7) derived from Human Histone H3-like centromeric protein A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:10-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CENPA

Target: CENPA (Centromere Protein A (CENPA))

Andere Bezeichnung: CENPA (CENPA Produkte)

Synonyme: CENP-A antikoerper, CenH3 antikoerper, Cenp-A antikoerper, cenpx antikoerper, cenp-a antikoerper, sim2 antikoerper, Cenp-a antikoerper, RGD1563607 antikoerper, CENPA antikoerper, centromere protein A antikoerper, centromere protein-A antikoerper, centromeric histone-3 like protein antikoerper, centromere-specific histone H3 CENP-A antikoerper, cenp-A antikoerper, centromere protein A L homeolog antikoerper, histone H3-like centromeric protein A antikoerper, CENPA antikoerper, Cenpa antikoerper, CENP-A antikoerper, cenpa antikoerper, cenp-A antikoerper, cnp1 antikoerper, HAN_3g422 antikoerper, Cenp-a antikoerper, cenpa.L antikoerper, CMU_016480 antikoerper

Hintergrund:

Background: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292).

Aliases: CENP A antibody, CENP-A antibody, cenpa antibody, CENPA_HUMAN antibody, Centromere autoantigen A antibody, Centromere protein A 17 kDa antibody, Centromere protein A antibody, Histone H3 like centromeric protein A antibody, Histone H3-like centromeric protein A antibody

UniProt: P49450

Pathways: Chromatin Binding, Maintenance of Protein Location