TNK2 Antikörper (pTyr284)

Produktnummer ABIN7138968

Produktdetails anti-TNK2 Antikörper

Target: TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))

Bindungsspezifität: pTyr284

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 284 (D-H-Y(p)-V-M) derived from Human ACK1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TNK2

Target: TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))

Andere Bezeichnung: TNK2 (TNK2 Produkte)

Synonyme: ACK antikoerper, ACK-1 antikoerper, ACK1 antikoerper, p21cdc42Hs antikoerper, AW552477 antikoerper, Ack antikoerper, Cdgip antikoerper, Pyk1 antikoerper, ack1 antikoerper, ackb antikoerper, tnk2 antikoerper, tnk2b antikoerper, wu:fj16g04 antikoerper, zgc:154019 antikoerper, tyrosine kinase non receptor 2 antikoerper, tyrosine kinase, non-receptor, 2 antikoerper, tyrosine kinase, non-receptor, 1 antikoerper, TNK2 antikoerper, Tnk2 antikoerper, tnk1 antikoerper

Hintergrund:

Background:

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes.

Manser E., Nature 363:364-367(1993).
Ota T., Nat. Genet. 36:40-45(2004).
Eisenmann K.M., Nat. Cell Biol. 1:507-513(1999)

Aliases: Acetate kinase 1 antibody, Acetokinase 1 antibody, ACK 1 antibody, ACK antibody, ACK-1 antibody, ACK1 antibody, ACK1_HUMAN antibody, Activated Cdc42 associated kinase 1 antibody, Activated CDC42 kinase 1 antibody, Activated p21cdc42Hs kinase antibody, FLJ44758 antibody, FLJ45547 antibody, p21cdc42Hs antibody, TNK 2 antibody, TNK2 antibody, Tyrosine kinase non receptor 2 antibody, Tyrosine kinase non receptor protein 2 antibody, Tyrosine kinase non-receptor protein 2 antibody

UniProt: Q07912