Glycogen Synthase Kinase 3 (GSK3) (pTyr216), (pTyr279) Antikörper

Produktnummer ABIN7138967

Produktdetails

Target: Glycogen Synthase Kinase 3 (GSK3)

Bindungsspezifität: pTyr216, pTyr279

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 279/216 (V-S-Y(p)-I-C) derived from Human GSK3alpha/beta .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Antigendetails

Target: Glycogen Synthase Kinase 3 (GSK3)

Andere Bezeichnung: GSK3A/GSK3B (GSK3 Produkte)

Synonyme: GSK3 antikoerper, GSK-3 antikoerper, C86142 antikoerper, GSK-3beta antikoerper, 7330414F15Rik antikoerper, 8430431H08Rik antikoerper, CG2621 antikoerper, DMSGG3 antikoerper, DMZ3K25Z antikoerper, Dm Zw3 antikoerper, Dmel\CG2621 antikoerper, Dmsgg3 antikoerper, EG:155E2.3 antikoerper, EG:BACR7C10.8 antikoerper, GSK antikoerper, GSK-3B antikoerper, GSK-3betaSgg antikoerper, GSK3-beta antikoerper, GSK3A antikoerper, GSK3Beta antikoerper, GSK3beta antikoerper, GSK3beta/SGG antikoerper, GSK3betagr antikoerper, GSKbeta antikoerper, Gsk-3 antikoerper, Gsk-3beta antikoerper, Gsk3 antikoerper, SGG antikoerper, SGG/GSK3b antikoerper, Sgg antikoerper, Sgg/GSK-3b antikoerper, Sgg/Zw3/GSK3 antikoerper, ZW-3 antikoerper, ZW3 antikoerper, Zw-3 antikoerper, Zw3 antikoerper, Zw3-sh antikoerper, Zw3/GSK3 antikoerper, Zw3[sgg] antikoerper, anon-WO03040301.254 antikoerper, gsk3 antikoerper, l(1)3Ba antikoerper, l(1)G0055 antikoerper, l(1)G0183 antikoerper, l(1)G0263 antikoerper, l(1)G0335 antikoerper, l(1)zw3 antikoerper, sgg-zw3 antikoerper, sgg/zw3 antikoerper, sgg10 antikoerper, sgg39 antikoerper, sgg46 antikoerper, zw-3 antikoerper, zw3 antikoerper, zw3(sgg) antikoerper, zw3/GSK3beta antikoerper, zw3/sgg antikoerper, zw3[sgg] antikoerper, zw[3] antikoerper, glycogen synthase kinase 3 beta antikoerper, shaggy antikoerper, Gsk3b antikoerper, sgg antikoerper

Hintergrund:

Background: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13, 137(1-2): 193-201 Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02, 316(2): 411-415 Fan G, et al. J Biol Chem 2003 Dec 26, 278(52): 52432-52436 Liao X, et al. Mol Cancer Ther 2003 Nov, 2(11): 1215-1222

Aliases: Factor A, GSK-3 alpha/beta, kinase GSK3-alpha/beta

UniProt: P49840, P49841