CAMK4 Antikörper (pThr196, pThr200)

Produktnummer ABIN7138796

Produktdetails anti-CAMK4 Antikörper

Target: CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))

Bindungsspezifität: pThr196, pThr200

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CAMK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of threonine 200 (M-K-T(p)-V-C) derived from Human CaMK4 or threonine 196 (M-K-T(p)-V-C) derived from Mouse CaMK4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CAMK4

Target: CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))

Andere Bezeichnung: CAMK4 (CAMK4 Produkte)

Synonyme: CaMK IV antikoerper, CaMK-GR antikoerper, IV antikoerper, caMK antikoerper, CAMK4 antikoerper, A430110E23Rik antikoerper, AI666733 antikoerper, CaMKIV antikoerper, CaMKIV/Gr antikoerper, D18Bwg0362e antikoerper, Ccdpk antikoerper, RATCCDPK antikoerper, camk4-A antikoerper, wu:fj42a03 antikoerper, zgc:110275 antikoerper, calcium/calmodulin dependent protein kinase IV antikoerper, calcium/calmodulin-dependent protein kinase IV antikoerper, calcium/calmodulin-dependent protein kinase IV L homeolog antikoerper, CAMK4 antikoerper, Camk4 antikoerper, camk4.L antikoerper, camk4 antikoerper

Hintergrund:

Background:

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2).

Oury F, et al. (2010)Genes Dev 24, 2330-42. Dias WB, Cheung WD, Wang Z, Hart GW (2009) J Biol Chem 284, 21327-37. Chow FA, Anderson KA, Noeldner PK, Means AR (2005)J Biol Chem 280, 20530-8.

Aliases: Brain Ca(2+) calmodulin dependent protein kinase type 4 antibody, Brain Ca(2+) calmodulin dependent protein kinase type IV antibody, Brain Ca++-calmodulin dependent protein kinase type IV antibody, Calcium / calmodulin dependent protein kinase type 4 catalytic chain antibody, Calcium / calmodulin dependent protein kinase type IV catalytic chain antibody, Calcium/calmodulin dependent protein kinase IV antibody, Calcium/calmodulin dependent protein kinase type IV antibody, Calcium/calmodulin-dependent protein kinase type IV antibody, CAM kinase 4 antibody, CAM kinase GR antibody, CAM kinase IV antibody, CAM kinase-GR antibody, CaMK 4 antibody, CAMK GR antibody, CaMK IV antibody, Camk4 antibody, CaMKGR antibody, IV antibody, KCC4_HUMAN antibody, MGC36771 antibody

UniProt: Q16566

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, Production of Molecular Mediator of Immune Response, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma