GRIN1/NMDAR1 Antikörper (pSer890)

Produktnummer ABIN7138721

Produktdetails anti-GRIN1/NMDAR1 Antikörper

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Bindungsspezifität: pSer890

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIN1/NMDAR1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine 890(A-S-S(p)-F-K) derived from Human NMDAR1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC:1:50-1:100, IF:1:100-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu GRIN1/NMDAR1

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Andere Bezeichnung: GRIN1 (GRIN1 Produkte)

Synonyme: GluN1 antikoerper, MRD8 antikoerper, NMDA1 antikoerper, NMDAR1 antikoerper, NR1 antikoerper, nmda1 antikoerper, nmdar1 antikoerper, GB19253 antikoerper, GRIN1 antikoerper, NMD-R1 antikoerper, Z16 antikoerper, GluRdelta1 antikoerper, GluRzeta1 antikoerper, M100174 antikoerper, Nmdar antikoerper, Rgsc174 antikoerper, NMDAR1.1 antikoerper, zgc:152678 antikoerper, glutamate ionotropic receptor NMDA type subunit 1 antikoerper, glutamate receptor, ionotropic, N-methyl D-aspartate 1 S homeolog antikoerper, NMDA receptor 1 antikoerper, G protein-regulated inducer of neurite outgrowth 1 antikoerper, glutamate receptor, ionotropic, NMDA1 (zeta 1) antikoerper, glutamate receptor, ionotropic, N-methyl D-aspartate 1a antikoerper, GRIN1 antikoerper, grin1.S antikoerper, grin1 antikoerper, Grin1 antikoerper, Nmdar1 antikoerper, Gprin1 antikoerper, grin1a antikoerper

Hintergrund:

Background:

NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

Guang Bai, J. Biol. Chem., Jan 1998, 273: 1086.
Guang Bai, J. Biol. Chem., Mar 1995, 270: 7737.
Mai T. Dang, PNAS, Oct 2006, 103: 15254 - 15259.

Aliases: GluN1 antibody, Glutamate [NMDA] receptor subunit zeta-1 antibody, Glutamate receptor ionotropic N methyl D aspartate 1 antibody, Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1 antibody, glutamate receptor ionotropic, NMDA 1 antibody, Grin1 antibody, MRD8 antibody, N methyl D aspartate receptor antibody, N methyl D aspartate receptor channel subunit zeta 1 antibody, N methyl D aspartate receptor subunit NR1 antibody, N-methyl-D-aspartate receptor subunit NR1 antibody, NMD-R1 antibody, NMDA 1 antibody, NMDA R1 antibody, NMDA receptor 1 antibody, NMDA1 antibody, NMDAR antibody, NMDZ1_HUMAN antibody, NR1 antibody

UniProt: Q05586

Pathways: Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity