ERCC6L Antikörper

Produktnummer ABIN7129394

Produktdetails anti-ERCC6L Antikörper

Target: ERCC6L (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like (ERCC6L))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERCC6L Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of Human ERCC6L

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA:1:2000-1:5000, IHC:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ERCC6L

Target: ERCC6L (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like (ERCC6L))

Andere Bezeichnung: ERCC6L (ERCC6L Produkte)

Synonyme: PICH antikoerper, RAD26L antikoerper, BC004701 antikoerper, D330021P09Rik antikoerper, RGD1565734 antikoerper, fc22h03 antikoerper, si:ch211-278b8.3 antikoerper, wu:fc22h03 antikoerper, ERCC excision repair 6 like, spindle assembly checkpoint helicase antikoerper, excision repair cross-complementing rodent repair deficiency complementation group 6 like antikoerper, DNA excision repair protein ERCC-6-like antikoerper, excision repair cross-complementation group 6-like antikoerper, ERCC6L antikoerper, Ercc6l antikoerper, LOC100373376 antikoerper, LOC100494766 antikoerper, LOC100552957 antikoerper, LOC100560751 antikoerper, LOC100563247 antikoerper, ercc6l antikoerper

Hintergrund:

Background: PICH (Plk1-interacting checkpoint helicase), also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1,250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain.

Aliases: ATP dependent helicase ERCC6 like antibody, ATP-dependent helicase ERCC6-like antibody, DNA excision repair protein ERCC 6 like antibody, DNA excision repair protein ERCC-6-like antibody, ERC6L_HUMAN antibody, ERCC 6L antibody, Ercc6l antibody, Excision repair cross complementing rodent repair deficiency complementation group 6 like antibody, Excision repair protein ERCC6 like antibody, FLJ20105 antibody, MGC131695 antibody, PICH antibody, Plk1 interacting checkpoint helicase antibody, PLK1-interacting checkpoint helicase antibody, SNF2/RAD54 family protein antibody, Tumor antigen BJ HCC 15 antibody, Tumor antigen BJ-HCC-15 antibody

UniProt: Q2NKX8