Rekombinanter LRRK2 Antikörper

Produktnummer ABIN7321713

Produktdetails anti-LRRK2 Antikörper

Target: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser LRRK2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human LRRK2

Klon: 4E9

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu LRRK2

Target: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Andere Bezeichnung: LRRK2 (LRRK2 Produkte)

Synonyme: LRRK2 antikoerper, AURA17 antikoerper, DARDARIN antikoerper, PARK8 antikoerper, RIPK7 antikoerper, ROCO2 antikoerper, 4921513O20Rik antikoerper, 9330188B09Rik antikoerper, AW561911 antikoerper, D630001M17Rik antikoerper, Gm927 antikoerper, cI-46 antikoerper, leucine-rich repeat kinase 2 antikoerper, leucine rich repeat kinase 2 antikoerper, lrrk2 antikoerper, LRRK2 antikoerper, Lrrk2 antikoerper

Hintergrund:

Background: Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH , and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.

Aliases: Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin), LRRK2, PARK8

UniProt: Q5S007

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development