NAC1 Antikörper

Produktnummer ABIN7126218

Produktdetails anti-NAC1 Antikörper

Target: NAC1 (NACC1) (Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NAC1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Spezifität: The BTB (broad-complex, tramtrack and bric a brac) domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. BTBD14B (BTB/POZ domain-containing protein 14B), also known as NACC1 (nucleus accumbens associated 1), BEND8 or NAC1, is a 527 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one BTB (POZ) domain. Existing as a homo-oligomer that interacts with HDAC3 and HDAC4, BTBD14B functions as a transcriptional repressor that influences the transcriptional activity of CRIF1 and is required for proteasome recruitment to the nucleus and cytoplasm in dendritic spines. BTBD14B is overexpressed in multiple carcinomas, suggesting a role in tumor development and metastasis.

Kreuzreaktivität (Details): Human

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human NACC1 protein

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/million cells),Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, MCF7 or K562 cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu NAC1

Target: NAC1 (NACC1) (Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1))

Andere Bezeichnung: NACC1 (NACC1 Produkte)

Synonyme: BEND8 antikoerper, BTBD14B antikoerper, BTBD30 antikoerper, NAC-1 antikoerper, NAC1 antikoerper, NACC1 antikoerper, 2010001H03Rik antikoerper, 4930511N13Rik antikoerper, Btbd14b antikoerper, Nac1 antikoerper, Nac-1 antikoerper, nucleus accumbens associated 1 antikoerper, nucleus accumbens associated 1, BEN and BTB (POZ) domain containing antikoerper, NACC1 antikoerper, Nacc1 antikoerper

Hintergrund: BEND8, BTB Domain Containing 14B, BTB/POZ domain-containing protein 14B, btbd14b, NAC-1, NAC1, Nucleus accumbens-associated protein 1,NACC1 / Nac1 / BTBD14B
Cellular localisation: Nucleus. Cytoplasm. Distribution in the cytoplasm is dependent on phosphorylation.

Molekulargewicht: 57kDa

Gen-ID: 112939, 531614

UniProt: Q96RE7