SNX6 Antikörper

Produktnummer ABIN7119365

Produktdetails anti-SNX6 Antikörper

Target: SNX6 (Sorting Nexin 6 (SNX6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNX6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: sorting nexin 6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu SNX6

Target: SNX6 (Sorting Nexin 6 (SNX6))

Andere Bezeichnung: SNX6 (SNX6 Produkte)

Synonyme: MGC75952 antikoerper, MGC80251 antikoerper, im:7146294 antikoerper, wu:fa55b10 antikoerper, zgc:110798 antikoerper, MSTP010 antikoerper, TFAF2 antikoerper, 2010006G21Rik antikoerper, 2610032J07Rik antikoerper, 2810425K19Rik antikoerper, AU018928 antikoerper, C85963 antikoerper, sorting nexin 6 antikoerper, sorting nexin 6 L homeolog antikoerper, snx6 antikoerper, snx6.L antikoerper, SNX6 antikoerper, Snx6 antikoerper

Hintergrund: Synonyms: Background:Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate(Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex(PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier(ETC)(Probable). Does not have in vitro vesicle-to-membrane remodeling activity(PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R(PubMed:17148574). May function as link between transport vesicles and dynactin(Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network(PubMed:20354142). Involved in E-cadherin sorting and degradation, inhibits PIP5K1C isoform 3-mediated E-cadherin degradation(PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B(By similarity). May contribute to transcription regulation(Probable).

Molekulargewicht: 47 kDa

Gen-ID: 58533

UniProt: Q9UNH7

Pathways: EGFR Signaling Pathway