MAP4K6 Antikörper

Produktnummer ABIN7116324

Produktdetails anti-MAP4K6 Antikörper

Target: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP4K6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: misshapen-like kinase 1(zebrafish)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu MAP4K6

Target: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Andere Bezeichnung: MINK1 (MINK1 Produkte)

Synonyme: MINK1 antikoerper, MINK antikoerper, B55 antikoerper, MAP4K6 antikoerper, YSK2 antikoerper, ZC3 antikoerper, hMINK antikoerper, hMINKbeta antikoerper, MEKKK 6 antikoerper, Map4k6 antikoerper, RP23-122P1.6 antikoerper, Ysk2 antikoerper, misshapen like kinase 1 antikoerper, misshapen-like kinase 1 antikoerper, misshapen-like kinase 1 (zebrafish) antikoerper, MINK1 antikoerper, Mink1 antikoerper

Hintergrund: Synonyms:B55, MAP4K6, Background:Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Molekulargewicht: 150 kDa

Gen-ID: 50488

UniProt: Q8N4C8

Pathways: Synaptic Membrane