KEAP1 Antikörper

Produktnummer ABIN7115610

Produktdetails anti-KEAP1 Antikörper

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KEAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: kelch-like ECH-associated protein 1

Klon: 9E2

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:1000, IHC: 1:50-1:500, IF: 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu KEAP1

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Andere Bezeichnung: KEAP1 (KEAP1 Produkte)

Synonyme: INrf2 antikoerper, KLHL19 antikoerper, INRF2 antikoerper, mKIAA0132 antikoerper, Inrf2 antikoerper, fb36f11 antikoerper, keap1 antikoerper, wu:fb36f11 antikoerper, KEAP1 antikoerper, klhl19 antikoerper, zgc:171654 antikoerper, kelch like ECH associated protein 1 antikoerper, kelch-like ECH-associated protein 1 antikoerper, Kelch-like ECH-associated protein 1 antikoerper, kelch-like ECH-associated protein 1a antikoerper, kelch like ECH associated protein 1 L homeolog antikoerper, kelch-like ECH-associated protein 1b antikoerper, KEAP1 antikoerper, Keap1 antikoerper, keap1a antikoerper, keap1 antikoerper, keap1.L antikoerper, keap1b antikoerper

Hintergrund: Synonyms:INRF2, KIAA0132, KLHL19 Background:Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Molekulargewicht: 55-70 kDa

Gen-ID: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location