Partner of Y14 and Mago (PYM1) Antikörper

Produktnummer ABIN7074992

Produktdetails

Target: Partner of Y14 and Mago (PYM1)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: Immunofluorescence (IF), Immunohistochemistry (IHC)

Kreuzreaktivität: Ratte

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse PYM

Anwendungsinformationen

Applikationshinweise: IHC/IF (M,R) 1:3000-1:6000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Antigendetails

Target: Partner of Y14 and Mago (PYM1)

Andere Bezeichnung: PYM

Hintergrund: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated.

Gen-ID: 78428

NCBI Accession: NP_001164340

UniProt: Q8CHP5