MIIP Antikörper

Produktnummer ABIN7074626

Produktdetails anti-MIIP Antikörper

Target: MIIP (Migration and Invasion Inhibitory Protein (MIIP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MIIP Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse MIIP

Anwendungsinformationen

Applikationshinweise: IHC/IF (H) 1:600-1:1200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu MIIP

Target: MIIP (Migration and Invasion Inhibitory Protein (MIIP))

Andere Bezeichnung: MIIP (MIIP Produkte)

Synonyme: IIP45 antikoerper, AA553001 antikoerper, AI853621 antikoerper, D4Wsu114e antikoerper, Iip45 antikoerper, migration and invasion inhibitory protein antikoerper, MIIP antikoerper, Miip antikoerper

Hintergrund: MIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposing effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression.

Gen-ID: 28010

NCBI Accession: NP_001020536

UniProt: A2A7Y5