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ROBO3 Antikörper

ROBO3 Reaktivität: Maus WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7261161
  • Target Alle ROBO3 Antikörper anzeigen
    ROBO3 (Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))
    Reaktivität
    • 21
    • 4
    • 3
    • 3
    • 3
    • 1
    Maus
    Wirt
    • 15
    • 4
    • 4
    Kaninchen
    Klonalität
    • 21
    • 2
    Polyklonal
    Konjugat
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ROBO3 Antikörper ist unkonjugiert
    Applikation
    • 14
    • 13
    • 5
    • 1
    Western Blotting (WB)
    Produktmerkmale
    Polyclonal Antibody
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein of human ROBO3 (NP_071765.2).
    Isotyp
    IgG
    Top Product
    Discover our top product ROBO3 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    ROBO3 (Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))
    Andere Bezeichnung
    ROBO3 (ROBO3 Produkte)
    Synonyme
    HGPPS antikoerper, HGPS antikoerper, RBIG1 antikoerper, RIG1 antikoerper, CG14345 antikoerper, CT17158 antikoerper, Robo-3 antikoerper, Robo3 antikoerper, dRobo-3 antikoerper, DmelCG5423 antikoerper, CG5423 antikoerper, ROBO3 antikoerper, robo3 antikoerper, DKFZp468G0223 antikoerper, Rbig1 antikoerper, Rig-1 antikoerper, Rig1 antikoerper, Robo3a antikoerper, Robo3b antikoerper, cb503 antikoerper, roundabout guidance receptor 3 antikoerper, roundabout 3 antikoerper, robo3 antikoerper, roundabout guidance receptor 3 L homeolog antikoerper, roundabout, axon guidance receptor, homolog 3 (Drosophila) antikoerper, ROBO3 antikoerper, robo3 antikoerper, Robo3 antikoerper, LOC658818 antikoerper, robo3.L antikoerper
    Hintergrund
    This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS), an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.
    Molekulargewicht

    Observed_MW: 200 kDa

    Calculated_MW: 110 kDa/148 kDa

    Gen-ID
    64221
    UniProt
    Q96MS0
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