IFITM1 Antikörper

Produktnummer ABIN7260992

Produktdetails anti-IFITM1 Antikörper

Target: IFITM1 (Interferon-Induced Transmembrane Protein 1 (IFITM1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFITM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human IFITM1 (NP_003632.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:200-1:2000 IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu IFITM1

Target: IFITM1 (Interferon-Induced Transmembrane Protein 1 (IFITM1))

Andere Bezeichnung: IFITM1 (IFITM1 Produkte)

Synonyme: 9-27 antikoerper, CD225 antikoerper, DSPA2a antikoerper, IFI17 antikoerper, LEU13 antikoerper, 1110036C17Rik antikoerper, Mil-2 antikoerper, Mil2 antikoerper, interferon induced transmembrane protein 1 antikoerper, interferon induced transmembrane protein 1 (9-27) antikoerper, Ifitm1 antikoerper, IFITM1 antikoerper

Hintergrund: Interferons (IFNs) are potential antitumor agents, as they exhibit antiproliferative and differentiating properties, in addition to functioning in the defense against microbial infections. IFN exposure induces the regulation of expression levels of cellular proteins that mediate the pleiotropic effects of interferons. These effects may be mediated by soluble factors or by cell-cell interactions involving specific membrane proteins. The IFITM family of proteins are transmembrane proteins so named because their expression is IFN-inducible. IFITM proteins have been found upregulated in human colorectal carcinomas. Both mouse IFITM1 (also known as CD225) and IFITM3 demonstrate expression on the cell surfaces of primordial germ cells in a developmentally-regulated manner. They presumably modulate cell adhesion and influence cell differentiation. IFITM1 activity is required for primordial germ cell transit, and IFITM1 acts as a repulsive molecule by repelling non-IFITM1-expressing primordial germ cells from the mesoderm into the endoderm.

Molekulargewicht:

Observed_MW: 17 kDa

Calculated_MW: 13 kDa

Gen-ID: 8519

UniProt: P13164