HMGCR Antikörper

Produktnummer ABIN7259042

Produktdetails anti-HMGCR Antikörper

Target: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HMGCR Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human HMGCR (NP_000850.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HMGCR

Target: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Andere Bezeichnung: HMGCR (HMGCR Produkte)

Synonyme: HMGR antikoerper, LDLCQ3 antikoerper, hmg-coa-r antikoerper, HMG-CoAR antikoerper, Red antikoerper, 3H3M antikoerper, BcDNA:LD15354 antikoerper, CG10367 antikoerper, Clb antikoerper, DmHMG-CoAr antikoerper, Dmel\\CG10367 antikoerper, HMGCR antikoerper, HMGCR_Dm antikoerper, HMGCoAR antikoerper, HMGCoARr antikoerper, HMGCoAr antikoerper, HmG-CoAR antikoerper, Hmg antikoerper, bro1 antikoerper, bs32f05.y1 antikoerper, clb antikoerper, hmgc antikoerper, hmgcr antikoerper, hmgrc antikoerper, l(3)01152 antikoerper, l(3)04684 antikoerper, hmgcr2 antikoerper, im:6912716 antikoerper, zgc:110746 antikoerper, 3-hydroxy-3-methylglutaryl-CoA reductase antikoerper, 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog antikoerper, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase antikoerper, HMG Coenzyme A reductase antikoerper, 3-hydroxy-3-methylglutaryl-CoA reductase b antikoerper, HMGCR antikoerper, hmgcr.L antikoerper, Hmgcr antikoerper, hmgcrb antikoerper

Hintergrund: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gen-ID: 3156

UniProt: P04035

Pathways: AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha