ZNHIT3 Antikörper

Produktnummer ABIN7248234

Produktdetails anti-ZNHIT3 Antikörper

Target: ZNHIT3 (Zinc Finger, HIT-Type Containing 3 (ZNHIT3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZNHIT3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of human ZNHIT3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:40-1:250, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.9 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ZNHIT3

Target: ZNHIT3 (Zinc Finger, HIT-Type Containing 3 (ZNHIT3))

Andere Bezeichnung: ZNHIT3 (ZNHIT3 Produkte)

Synonyme: Myohd1 antikoerper, Trip3 antikoerper, TRIP3 antikoerper, TRIP-3 antikoerper, zinc finger, HIT type 3 antikoerper, zinc finger HIT-type containing 3 antikoerper, zinc finger, HIT-type containing 3 antikoerper, Znhit3 antikoerper, ZNHIT3 antikoerper

Hintergrund: ZNHIT3 (zinc finger, HIT-type containing 3), also known as TRIP3 (thyroid receptor-interacting protein 3) or HNF-4a coactivator, is a 155 amino acid protein that contains one HIT-type zinc finger and regulates PPAR-mediated adipocyte differentiation. ZNHIT3 also coactivates HNF-4, and as a thyroid receptor interacting protein, ZNHIT3 interacts with the ligand binding domain of the thyroid receptor. The gene encoding ZNHIT3 maps to human chromosome 17, which comprises over 2.5 % of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

UniProt: Q15649