ZZZ3 Antikörper

Produktnummer ABIN7245926

Produktdetails anti-ZZZ3 Antikörper

Target: ZZZ3 (Zinc Finger, ZZ-Type Containing 3 (ZZZ3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZZZ3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of human ZZZ3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:40-1:250, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.8 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ZZZ3

Target: ZZZ3 (Zinc Finger, ZZ-Type Containing 3 (ZZZ3))

Andere Bezeichnung: ZZZ3 (ZZZ3 Produkte)

Synonyme: 3110065C23Rik antikoerper, 6430567E01Rik antikoerper, AA408566 antikoerper, AI481057 antikoerper, AW556059 antikoerper, R75514 antikoerper, si:ch211-284g18.3 antikoerper, wu:fj98c02 antikoerper, ATAC1 antikoerper, RGD1565468 antikoerper, zinc finger ZZ-type containing 3 antikoerper, zinc finger, ZZ-type containing 3 antikoerper, ZZ-type zinc finger-containing protein 3 antikoerper, zinc finger, ZZ domain containing 3 antikoerper, ZZZ3 antikoerper, zzz3 antikoerper, LOC100619668 antikoerper, Zzz3 antikoerper

Hintergrund: ZZZ3 (ZZ-type zinc finger-containing protein 3) is a 903 amino acid protein that contains one HTH myb-type DNA-binding domain and one ZZ-type zinc finger. Phosphorylated upon DNA damage by ATM or ATR, ZZZ3 is a subunit of the ATAC complex, which is composed of GCN5, CRP2BP, ADA3, TADA2L, DR1, CCDC101, YEATS2, WDR5 and MBIP. The ATAC complex has histone acetyltransferase activity on histones H3 and H4. ZZZ3 is expressed as four isoforms produced by alternative splicing and is encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8 % of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.

UniProt: Q8IYH5

Pathways: Chromatin Binding