JNK2 Antikörper

Produktnummer ABIN7244543

Produktdetails anti-JNK2 Antikörper

Target: JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JNK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human MAPK9

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:25-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu JNK2

Target: JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))

Andere Bezeichnung: JNK2 (MAPK9 Produkte)

Synonyme: MAPK9 antikoerper, JNK-55 antikoerper, JNK2 antikoerper, JNK2A antikoerper, JNK2ALPHA antikoerper, JNK2B antikoerper, JNK2BETA antikoerper, PRKM9 antikoerper, SAPK antikoerper, SAPK1a antikoerper, p54a antikoerper, p54aSAPK antikoerper, AI851083 antikoerper, Prkm9 antikoerper, JNK2-ALPHA1 antikoerper, MAP kinase 9 antikoerper, mitogen-activated protein kinase 9 antikoerper, MAP kinase 9 antikoerper, MAPK9 antikoerper, Mapk9 antikoerper, MPK9 antikoerper

Hintergrund: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Molekulargewicht:

Observed_MW: Refer to figures

Calculated_MW: 48 kDa

NCBI Accession: NP_620707

UniProt: P45984

Pathways: MAPK Signalweg, WNT Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteine