CXCR2 Antikörper

Produktnummer ABIN7002451

Produktdetails anti-CXCR2 Antikörper

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human CXCR2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:200-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CXCR2

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Andere Bezeichnung: IL8RB (CXCR2 Produkte)

Synonyme: CD182 antikoerper, CDw128b antikoerper, CMKAR2 antikoerper, IL8R2 antikoerper, IL8RA antikoerper, IL8RB antikoerper, CXC-R2 antikoerper, CXCR-2 antikoerper, CD128 antikoerper, CDw128 antikoerper, Cmkar2 antikoerper, Gpcr16 antikoerper, IL-8Rh antikoerper, IL-8rb antikoerper, Il8rb antikoerper, mIL-8RH antikoerper, C-X-C motif chemokine receptor 2 antikoerper, chemokine (C-X-C motif) receptor 2 antikoerper, Cxcr2 antikoerper, CXCR2 antikoerper

Hintergrund: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Molekulargewicht: 41 kDa

NCBI Accession: NP_001548

UniProt: P25025

Pathways: cAMP Metabolic Process