HMGB4 Antikörper

Produktnummer ABIN7239995

Produktdetails anti-HMGB4 Antikörper

Target: HMGB4 (High Mobility Group Box 4 (HMGB4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HMGB4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human HMGB4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:200-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HMGB4

Target: HMGB4 (High Mobility Group Box 4 (HMGB4))

Andere Bezeichnung: HMGB4 (HMGB4 Produkte)

Synonyme: HMGB4 antikoerper, dJ1007G16.5 antikoerper, 1700001F22Rik antikoerper, AI326135 antikoerper, high mobility group box 4 antikoerper, high-mobility group box 4 antikoerper, HMGB4 antikoerper, Hmgb4 antikoerper

Hintergrund: High mobility group protein B4is atranscription factorthat in humans is encoded by theHMGB4gene.HMGB4 is strongly and preferentially expressed in the adult mouse testis and weakly in the brain, but not in many other tissues. HMGB4 associates with chromatin, and in transfection assays, in contrast to HMGB1, it acts as a potent transcriptional repressor. During spermatogenesis, HMGB4 is present in the euchromatin of late pachytene spermatocytes and haploid round spermatids, whereas stronger expression is observed during the elongation phase, where it localizes to the basal pole of the nucleus in a manner mutually exclusive with H1FNT (H1T2) localized at the apical pole. HMGB4 basal localization is lost in H1FNT-mutant spermatids, showing that H1FNT provides a positional cue for organizing chromatin domains within the nucleus. These results show that HMGB4 and H1FNT specify distinct chromatin domains at the apical and basal poles of the elongating spermatid nucleus.

Molekulargewicht: 22 kDa

UniProt: Q8WW32