HDBP-2 antikoerper, HDBP2 antikoerper, HDRF-2 antikoerper, PBF antikoerper, PRF-1 antikoerper, PRF1 antikoerper, Si-1-8-14 antikoerper, sb:cb866 antikoerper, zgc:55309 antikoerper, si:ch211-89p3.1 antikoerper, si:ch211-223o11.1 antikoerper, ZNF395 antikoerper, pbf antikoerper, prf1 antikoerper, hdbp2 antikoerper, prf-1 antikoerper, si-1-8-14 antikoerper, BC053701 antikoerper, Gm910 antikoerper, si:ch211-63o20.5 antikoerper, wu:fa14e01 antikoerper, zgc:158367 antikoerper, zinc finger protein 395 antikoerper, zinc finger protein 395 S homeolog antikoerper, family with sequence similarity 49, member A antikoerper, zinc finger protein 395b antikoerper, zinc finger protein 395a antikoerper, ZNF395 antikoerper, znf395.S antikoerper, fam49a antikoerper, znf395 antikoerper, Zfp395 antikoerper, Znf395 antikoerper, znf395b antikoerper, znf395a antikoerper
Hintergrund
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF395 (Zinc finger protein 395), also known as PBF (Papillomavirus-binding factor) and HDBP2 (Huntington disease gene regulatory region-binding protein 2), is a 513 amino acid protein that contains one C2H2-type zinc finger. ZNF395 binds to the 3'-CCGG-5' sequence within the papillomavirus promoter adjacent to a RUNX1-binding motif. It has also been established that ZNF395 binds to a seven base pair region within the Huntington's disease (HD) gene promoter, an essential element for HD gene expression. ZNF395 is widely expressed and probably shuttles between the nucleus and cytoplasm.