CRH Antikörper (N-Term)

Produktnummer ABIN6992006

Produktdetails anti-CRH Antikörper

Target: CRH (Corticotropin Releasing Hormone (CRH))

Bindungsspezifität: AA 30-80, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: CRH antibody is human specific.

Aufreinigung: CRH antibody is affinity chromatography purified via peptide column.

Immunogen: CRH antibody was raised against a 16 amino acid peptide near the amino terminus of human CRH. The immunogen is located within amino acids 30 - 80 of CRH.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CRH antibody can be used for detection of CRH by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CRH antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CRH antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu CRH

Target: CRH (Corticotropin Releasing Hormone (CRH))

Andere Bezeichnung: CRH (CRH Produkte)

Synonyme: CRF antikoerper, Gm1347 antikoerper, crf antikoerper, crh antikoerper, zgc:101864 antikoerper, CRH antikoerper, corticoliberin antikoerper, crhb antikoerper, crh.1-a antikoerper, crha antikoerper, corticotropin releasing hormone antikoerper, corticotropin releasing hormone b antikoerper, corticotropin releasing hormone S homeolog antikoerper, corticotropin releasing hormone L homeolog antikoerper, Crh antikoerper, CRH antikoerper, crhb antikoerper, crh antikoerper, crh.S antikoerper, crh.L antikoerper

Hintergrund: Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1). In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2). Marked reduction in this protein has been observed in association with Alzheimer disease (3).

Molekulargewicht: Predicted: 22 kDa

Observed: 29 kDa

Gen-ID: 1392

NCBI Accession: NP_000747

UniProt: P06850

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour