APOBEC3B Antikörper (N-Term)

Produktnummer ABIN6991981

Produktdetails anti-APOBEC3B Antikörper

Target: APOBEC3B (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3B (APOBEC3B))

Bindungsspezifität: AA 20-70, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APOBEC3B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: APOBEC3B antibody is human, mouse and rat reactive . At least three isoforms of APOBEC3B are known to exist, this antibody will detect all three. APOBEC3B antibody may cross-react with APOBEC3D.

Aufreinigung: APOBEC3B antibody is affinity chromatography purified via peptide column.

Immunogen: APOBEC3B antibody was raised against a 14 amino acid peptide near the amino terminus of human APOBEC3B. The immunogen is located within amino acids 20 - 70 of APOBEC3B.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: APOBEC3B antibody can be used for detection of APOBEC3B by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: APOBEC3B Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: APOBEC3B antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu APOBEC3B

Target: APOBEC3B (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3B (APOBEC3B))

Andere Bezeichnung: APOBEC3B (APOBEC3B Produkte)

Synonyme: A3B antikoerper, APOBEC1L antikoerper, ARCD3 antikoerper, ARP4 antikoerper, DJ742C19.2 antikoerper, PHRBNL antikoerper, bK150C2.2 antikoerper, APOBEC3B antikoerper, Apobec3 antikoerper, Apobec3f antikoerper, APOBEC3F antikoerper, APOBEC3Z2 antikoerper, APOBEC3Z3 antikoerper, apolipoprotein B mRNA editing enzyme catalytic subunit 3B antikoerper, APOBEC3B antikoerper, Apobec3b antikoerper

Hintergrund: The Apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytosine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates (1). Similar to TRIM5? which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection (2,3). APOBEC3B has also been shown to be upregulated in several cancers, it is thought that APOBEC3B-catalyzed genomic uracil lesions are responsible for a large proportion of mutations in multiple distinct cancers (4).

Molekulargewicht: Predicted: 42 kDa

Observed: 48 kDa

Gen-ID: 9582

NCBI Accession: NP_004891

UniProt: Q9UH17