TRPV4 Antikörper (AA 380-430)

Produktnummer ABIN6991967

Produktdetails anti-TRPV4 Antikörper

Target: TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))

Bindungsspezifität: AA 380-430

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRPV4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: TRPV4 antibody is human specific. At least six isoforms of TRPV4 are known to exist. This antibody is predicted to not cross-react with other TRP protein family members.

Aufreinigung: TRPV4 antibody is affinity chromatography purified via peptide column.

Immunogen: TRPV4 antibody was raised against an 18 amino acid peptide near the center of human TRPV4. The immunogen is located within amino acids 380 - 430 of TRPV4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TRPV4 antibody can be used for detection of TRPV4 by Western blot at 1 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TRPV4 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TRPV4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu TRPV4

Target: TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))

Andere Bezeichnung: TRPV4 (TRPV4 Produkte)

Synonyme: wu:fp52e02 antikoerper, CMT2C antikoerper, HMSN2C antikoerper, OTRPC4 antikoerper, SMAL antikoerper, SPSMA antikoerper, SSQTL1 antikoerper, TRP12 antikoerper, VRL2 antikoerper, VROAC antikoerper, 0610033B08Rik antikoerper, Trp12 antikoerper, VR-OAC antikoerper, VRL-2 antikoerper, Otrpc4 antikoerper, Vroac antikoerper, transient receptor potential cation channel, subfamily V, member 4 antikoerper, transient receptor potential cation channel subfamily V member 4 antikoerper, trpv4 antikoerper, TRPV4 antikoerper, Trpv4 antikoerper

Hintergrund: The transient receptor potential (TRP) protein family consists of a diverse group of cation channels functioning in a variety of homeostatic and regulatory pathways. Four subfamilies exist, based on channel domain homology: C type (canonical), V type (vanilloid receptor related), M type (melastatin related) and P type (PKD) (1). TRPV4, belongs to the V type subfamily and plays a role in systemic osmoregulation (2,3). TRPV4 is a calcium channel multi-pass membrane protein activated by various stimuli, including thermal stress, fatty acid metabolites and hypotonicity (3). TRPV4 is highly expressed in lung and kidney and widely expressed in brain. It plays an important role in regulating neural excitability (4).

Molekulargewicht: Predicted: 96 kDa

Observed: 100 kDa

Gen-ID: 59341

NCBI Accession: NP_067638

UniProt: Q9HBA0

Pathways: Hormone Transport, Cell-Cell Junction Organization