Western Blotting (WB), Immunofluorescence (IF), ELISA
Spezifität
At least two isoforms of FAM193B are known to exist, this antibody will detect both isoforms.
Aufreinigung
FAM193B Antibody is affinity chromatography purified via peptide column.
Immunogen
FAM193B antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human FAM193B. The immunogen is located within amino acids 120 - 170 of FAM193B.
FAM193B
Reaktivität: Human
WB, IF, EIA
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
FAM193B antibody can be used for detection of FAM193B by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
FAM193B Antibody is supplied in PBS containing 0.02 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C,4 °C
Informationen zur Lagerung
FAM193B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Target
FAM193B
(Family with Sequence Similarity 193, Member B (FAM193B))
IRIZIO antikoerper, Kiaa1931 antikoerper, family with sequence similarity 193 member B antikoerper, family with sequence similarity 193, member B antikoerper, FAM193B antikoerper, Fam193b antikoerper
Hintergrund
FAM193B Antibody: FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.