ZMYM2 Antikörper (N-Term)

Produktnummer ABIN6991475

Produktdetails anti-ZMYM2 Antikörper

Target: ZMYM2 (Zinc Finger, MYM-Type 2 (ZMYM2))

Bindungsspezifität: AA 120-170, N-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZMYM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: At least two isoforms of ZMYM2 are known to exist, this antibody will detect only the longest isoform. ZMYM2 antibody is predicted to not cross-react with other ZMYM protein family members.

Aufreinigung: ZMYM2 Antibody is affinity chromatography purified via peptide column.

Immunogen: ZMYM2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ZMYM2. The immunogen is located within amino acids 120 - 170 of ZMYM2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ZMYM2 antibody can be used for detection of ZMYM2 by Western blot at 0. 125 - 0.25 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ZMYM2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ZMYM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu ZMYM2

Target: ZMYM2 (Zinc Finger, MYM-Type 2 (ZMYM2))

Andere Bezeichnung: ZMYM2 (ZMYM2 Produkte)

Synonyme: ZMYM2 antikoerper, ZNF198 antikoerper, fc07a10 antikoerper, wu:fc07a10 antikoerper, si:dkey-51d17.6 antikoerper, fim antikoerper, mym antikoerper, ramp antikoerper, scll antikoerper, zfp198 antikoerper, znf198 antikoerper, MGC83724 antikoerper, FIM antikoerper, MYM antikoerper, RAMP antikoerper, SCLL antikoerper, 5830413P05Rik antikoerper, Zfp198 antikoerper, Znf198 antikoerper, zinc finger MYM-type containing 2 antikoerper, zinc finger, MYM-type 2 antikoerper, zinc finger MYM-type containing 2 L homeolog antikoerper, ZMYM2 antikoerper, zmym2 antikoerper, zmym2.L antikoerper, Zmym2 antikoerper

Hintergrund: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression (1). The protein folding and the DNA binding ability are governed by the coordination of a zinc ion (1-3). As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes (4). Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL) (5).

Gen-ID: 7750

UniProt: Q9UBW7