ZC3H12A Antikörper (AA 330-380)

Produktnummer ABIN6991306

Produktdetails anti-ZC3H12A Antikörper

Target: ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))

Bindungsspezifität: AA 330-380

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZC3H12A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: This ZC3H12A antibody is predicted to have no cross-reactivity to other members of the ZC3H12 protein family.

Aufreinigung: ZC3H12A Antibody is affinity chromatography purified via peptide column.

Immunogen: ZC3H12A antibody was raised against a 17 amino acid synthetic peptide near the center of human ZC3H12A. The immunogen is located within amino acids 330 - 380 of ZC3H12A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ZC3H12A antibody can be used for detection of ZC3H12A by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ZC3H12A Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ZC3H12A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu ZC3H12A

Target: ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))

Andere Bezeichnung: ZC3H12A (ZC3H12A Produkte)

Synonyme: CGA antikoerper, MCPIP antikoerper, MCPIP1 antikoerper, RP3-423B22.1 antikoerper, dJ423B22.1 antikoerper, BC036563 antikoerper, Mcpip1 antikoerper, RGD1306776 antikoerper, chromogranin A antikoerper, zinc finger CCCH-type containing 12A antikoerper, zinc finger CCCH type containing 12A antikoerper, CHGA antikoerper, ZC3H12A antikoerper, Zc3h12a antikoerper

Hintergrund: ZC3H12A Antibody: ZC3H12A, also known as MCPIP, is an essential member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation and may be involved in host immunity and inflammatory diseases. ZC3H12A has RNase activity that prevents some immune disorders by directly affecting the mRNA stability of interleukins such as IL-6 and IL12p40. Mice lacking the ZC3H12A gene suffered from severe anemia, and most dies within 12 weeks. Overexpression of ZC3H12A causes ER stress and induces a number of genes involved in apoptosis and autophagy, including JNK, PUMA, and beclin-1 in cardiac myoblasts, leading to cell death. ZC3H12A can also induce adipogenesis in 3T3-L1 pre-adipocytes in the absence of PPAPgamma, demonstrating the complex roles ZC3H12A plays.

Molekulargewicht: Predicted: 66 kDa

Observed: 6 kDa

Gen-ID: 80149

NCBI Accession: NP_079355

UniProt: Q5D1E8

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of fat Cell Differentiation