FAM59A Antikörper (C-Term)

Produktnummer ABIN6991222

Produktdetails anti-FAM59A Antikörper

Target: FAM59A (Family with Sequence Similarity 59, Member A (FAM59A))

Bindungsspezifität: AA 630-680, C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM59A Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Aufreinigung: FAM59A Antibody is affinity chromatography purified via peptide column.

Immunogen: FAM59A antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FAM59A. The immunogen is located within amino acids 630 - 680 of FAM59A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FAM59A antibody can be used for detection of FAM59A by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: FAM59A Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: FAM59A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu FAM59A

Target: FAM59A (Family with Sequence Similarity 59, Member A (FAM59A))

Andere Bezeichnung: FAM59A (FAM59A Produkte)

Synonyme: C18orf11 antikoerper, FAM59A antikoerper, Gm944 antikoerper, C86169 antikoerper, Fam59a antikoerper, mKIAA4238 antikoerper, fam59a antikoerper, zgc:55634 antikoerper, GRB2 associated regulator of MAPK1 subtype 1 antikoerper, GRB2 associated, regulator of MAPK1 antikoerper, GAREM1 antikoerper, Garem1 antikoerper, garem antikoerper

Hintergrund: FAM59A Antibody: FAM59A, also known as GAREM, was initially identified through a mass spectroscoptic method that measures different phosphotyrosine states of proteins in response to different cell stimuli. FAM59A is a downstream molecule in the EGF signaling pathway that is tyrosine-phosphorylated, and this phosphorylation is needed for the binding of Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. ERK activation in response to EGF stimulation is regulated by FAM59A in COS-7 and HeLa cells, and the overexpression of FAM59A stimulated cell proliferation and colony formation in soft agar, suggesting that FAM59A might be a critical protein with roles in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.

Gen-ID: 64762

UniProt: Q9H706

Pathways: EGFR Signaling Pathway