LZTS2 Antikörper (C-Term)

Produktnummer ABIN6991079

Produktdetails anti-LZTS2 Antikörper

Target: LZTS2 (Leucine Zipper, Putative Tumor Suppressor 2 (LZTS2))

Bindungsspezifität: AA 570-620, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LZTS2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: LZTS2 antibody is predicted to not cross-react with other LZTS family members.

Aufreinigung: LZTS2 Antibody is affinity chromatography purified via peptide column.

Immunogen: LZTS2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human LZTS2. The immunogen is located within amino acids 570 - 620 of LZTS2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: LZTS2 antibody can be used for detection of LZTS2 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: LZTS2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: LZTS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu LZTS2

Target: LZTS2 (Leucine Zipper, Putative Tumor Suppressor 2 (LZTS2))

Andere Bezeichnung: LZTS2 (LZTS2 Produkte)

Synonyme: lapser1 antikoerper, MGC89253 antikoerper, si:dkey-250a11.1 antikoerper, LAPSER1 antikoerper, BC014695 antikoerper, mKIAA1813 antikoerper, Lapser1 antikoerper, leucine zipper, putative tumor suppressor 2 antikoerper, leucine zipper tumor suppressor 2 antikoerper, leucine zipper, putative tumor suppressor 2a antikoerper, leucine zipper, putative tumor suppressor 2 S homeolog antikoerper, lzts2 antikoerper, LZTS2 antikoerper, lzts2a antikoerper, Lzts2 antikoerper, lzts2.S antikoerper

Hintergrund: LZTS2 Antibody: The leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1), a member of the LZTS family, is a negative regulator of the Wnt signaling pathway. It represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. LZTS2 is involved in cytokinesis and regulates katanin-mediated microtubule severing and release from the centrosome. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. LZTS2 is highly expressed in testis and prostate, but it is deleted in multiple cancers, including prostate tumors, suggesting that LZTS2 acts as a potential tumor suppressor.

Gen-ID: 84445

NCBI Accession: NP_115805

UniProt: Q9BRK4