ZFYVE26 Antikörper (C-Term)

Produktnummer ABIN6991064

Produktdetails anti-ZFYVE26 Antikörper

Target: ZFYVE26 (Zinc Finger, FYVE Domain Containing 26 (ZFYVE26))

Bindungsspezifität: AA 1710-1760, C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZFYVE26 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Spezifität: Multiple isoforms of SPG15 are known to exist.

Aufreinigung: SPG15 Antibody is affinity chromatography purified via peptide column.

Immunogen: SPG15 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human SPG15. The immunogen is located within amino acids 1710 - 1760 of SPG15.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SPG15 antibody can be used for detection of SPG15 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SPG15 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SPG15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu ZFYVE26

Target: ZFYVE26 (Zinc Finger, FYVE Domain Containing 26 (ZFYVE26))

Andere Bezeichnung: SPG15 (ZFYVE26 Produkte)

Synonyme: wu:fc33a03 antikoerper, FYVE-CENT antikoerper, SPG15 antikoerper, 4930465A13 antikoerper, 9330197E15Rik antikoerper, A630028O16Rik antikoerper, Gm893 antikoerper, mKIAA0321 antikoerper, zinc finger, FYVE domain containing 26 antikoerper, zinc finger FYVE-type containing 26 antikoerper, zfyve26 antikoerper, ZFYVE26 antikoerper, Zfyve26 antikoerper

Hintergrund: SPG15 Antibody: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.  Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking.

Molekulargewicht: Predicted: 280 kDa

Observed: 260 kDa

Gen-ID: 23503

UniProt: Q68DK2