AIPL1 Antikörper (C-Term)

Produktnummer ABIN6990999

Produktdetails anti-AIPL1 Antikörper

Target: AIPL1 (Aryl Hydrocarbon Receptor Interacting Protein-Like 1 (AIPL1))

Bindungsspezifität: AA 290-340, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AIPL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Aipl1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Aipl1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human Aipl1. The immunogen is located within amino acids 290 - 340 of Aipl1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Aipl1 antibody can be used for detection of Aipl1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Aipl1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Aipl1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu AIPL1

Target: AIPL1 (Aryl Hydrocarbon Receptor Interacting Protein-Like 1 (AIPL1))

Andere Bezeichnung: Aipl1 (AIPL1 Produkte)

Synonyme: AIPL1 antikoerper, lca4 antikoerper, aipl2 antikoerper, AIPL2 antikoerper, LCA4 antikoerper, A930007I01Rik antikoerper, aryl hydrocarbon receptor interacting protein like 1 antikoerper, aryl hydrocarbon receptor-interacting protein-like 1 antikoerper, AIPL1 antikoerper, aipl1 antikoerper, Aipl1 antikoerper

Hintergrund: Aipl1 Antibody: Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.

Gen-ID: 23746

NCBI Accession: NP_055151

UniProt: Q9NZN9