Hax1b (N-Term) Antikörper

Produktnummer ABIN6990947

Produktdetails

Target: Hax1b

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: ELISA, Western Blotting (WB)

Spezifität: At least four isoforms of Hax1 are known to exist. This antibody is predicted to recognize Hax1b.

Aufreinigung: Hax1b Antibody is affinity chromatography purified via peptide column.

Immunogen: Hax1b antibody was raised against a 10 amino acid synthetic peptide near the amino terminus of human Hax1b. The immunogen is located within the first 50 amino acids of Hax1b.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Hax1b antibody can be used for detection of Hax1b by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Hax1b Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Hax1b antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Antigendetails

Target: Hax1b

Hintergrund: Hax1b Antibody: The HS-1 associated protein X-1 (Hax1) was initially identified in a yeast two-hybrid assay on the basis of its ability to bind to the hemapoietic cell-specific protein 1 (HS-1). Hax1 possesses anti-apoptotic activity and is structurally related to Bcl-2 family members, including the presence of BH1- and BH2-like domains. It has recently been shown to interact with HIV viral protein R (Vpr), a protein required for viral pathogenesis of HIV and linked to T-cell apoptosis through activation of caspases 3 and 9. Other studies indicate that Hax1-mediated processing of HtrA2 (also known as Omi) by the mitochondrial protease PARL allows survival of lymphocytes and neurons when cytokines are limiting.

Gen-ID: 10456

NCBI Accession: NP_001018238

UniProt: O00165