GPER Antikörper (AA 21-120) (Alexa Fluor 350)

Produktnummer ABIN6976948

Produktdetails anti-GPER Antikörper (Alexa Fluor 350)

Target: GPER (G Protein-Coupled Estrogen Receptor 1 (GPER))

Bindungsspezifität: AA 21-120

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPER Antikörper ist konjugiert mit Alexa Fluor 350

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GPR30

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu GPER

Target: GPER (G Protein-Coupled Estrogen Receptor 1 (GPER))

Andere Bezeichnung: GPR30, (GPER Produkte)

Synonyme: CEPR antikoerper, CMKRL2 antikoerper, DRY12 antikoerper, FEG-1 antikoerper, GPCR-Br antikoerper, GPER antikoerper, GPR30 antikoerper, LERGU antikoerper, LERGU2 antikoerper, LyGPR antikoerper, 6330420K13Rik antikoerper, Ceprl antikoerper, Gper antikoerper, Gpr30 antikoerper, GPR41 antikoerper, GPCR30 antikoerper, G protein-coupled estrogen receptor 1 antikoerper, GPER1 antikoerper, GPER antikoerper, Gper1 antikoerper

Hintergrund:

Synonyms: G Protein Coupled Receptor 30, G-protein coupled receptor 30, G-protein coupled estrogen receptor 1, Membrane estrogen receptor, mER, Chemokine receptor-like 2, IL8-related receptor DRY12, Flow-induced endothelial G-protein coupled receptor 1, FEG-1, Lymphocyte-derived G-protein coupled receptor, LYGPR, GPCR-BR, CEPR, CMKRL2, DRY12, GPER.

Background: G protein-coupled receptors (GPRs, or GPCRs) contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops and transduce a variety of hormone, endogenous peptide, and neurotransmitter signals into intracellular effects via G proteins. GRP30 is a member of this family and is an orphan receptor. GPR30 expression has been reported in brain, breast carcinoma, blood, bone marrow, CNS, heart, liver, lung, lymph node, placenta, and spleen. In brain, GPR30 is expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen. However, unlike other known G protein-coupled receptors, GPR30 localizes to the endoplasmic reticulum, where it specifically binds estrogen and estrogen derivatives.

Gen-ID: 2852

UniProt: Q99527

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process