RPE65 Antikörper

Produktnummer ABIN6944796

Produktdetails anti-RPE65 Antikörper

Target: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser RPE65 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Human RPE65 aa 450 to the C-terminus

Klon: 2C1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu RPE65

Target: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Andere Bezeichnung: RPE65 (RPE65 Produkte)

Synonyme: LCA2 antikoerper, RP20 antikoerper, mRPE65 antikoerper, rd12 antikoerper, sRPE65 antikoerper, 65kDa antikoerper, A930029L06Rik antikoerper, Mord1 antikoerper, DRPE65 antikoerper, RPE65 antikoerper, anon-WO0148162.1 antikoerper, anon-WO0148163.1 antikoerper, beta-diox antikoerper, DmelCG9347 antikoerper, CG9347 antikoerper, MGC52887 antikoerper, MGC154296 antikoerper, MGC85437 antikoerper, rpe65 antikoerper, RPE56c antikoerper, si:ch211-198n5.12 antikoerper, 13cIMH antikoerper, RPE56b antikoerper, rpepb antikoerper, si:ch211-198n5.5 antikoerper, wu:fc74c09 antikoerper, zgc:110538 antikoerper, RPE56a antikoerper, rpepa antikoerper, zgc:73213 antikoerper, RPE65, retinoid isomerohydrolase antikoerper, retinal pigment epithelium 65 antikoerper, neither inactivation nor afterpotential B antikoerper, retinal pigment epithelium-specific protein 65kDa S homeolog antikoerper, retinal pigment epithelium-specific protein 65kDa L homeolog antikoerper, RPE65 homolog antikoerper, retinal pigment epithelium-specific protein 65kDa antikoerper, retinal pigment epithelium-specific protein 65c antikoerper, retinal pigment epithelium-specific protein 65b antikoerper, retinal pigment epithelium-specific protein 65a antikoerper, RPE65 antikoerper, Rpe65 antikoerper, ninaB antikoerper, rpe65.S antikoerper, rpe65.L antikoerper, rpe65 antikoerper, rpe65c antikoerper, rpe65b antikoerper, rpe65a antikoerper

Hintergrund:

Synonyms: Retinoid isomerohydrolase, All-trans-retinyl-palmitate hydrolase, Retinal pigment epithelium-specific 65 kDa protein, Retinol isomerase, RPE65

Background: Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17848510). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity).

Gen-ID: 6121

UniProt: Q16518