FBXO5 Antikörper

Produktnummer ABIN6943441

Produktdetails anti-FBXO5 Antikörper

Target: FBXO5 (F-Box Protein 5 (FBXO5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser FBXO5 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant protein within human Emi1 aa 50-250.

Klon: 4G10

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu FBXO5

Target: FBXO5 (F-Box Protein 5 (FBXO5))

Andere Bezeichnung: FBXO5 (FBXO5 Produkte)

Synonyme: EMI1 antikoerper, FBX5 antikoerper, Fbxo31 antikoerper, 2510044I10Rik antikoerper, C85305 antikoerper, Emi1 antikoerper, emi1 antikoerper, fc65h02 antikoerper, wu:fc65h02 antikoerper, wu:fe06e07 antikoerper, wu:fz79f03 antikoerper, zgc:136397 antikoerper, zgc:158541 antikoerper, fbx5 antikoerper, Fbxo5 antikoerper, ACYPI007854 antikoerper, fbxo5 antikoerper, F-box protein 5 antikoerper, F-box only protein 5 antikoerper, F-box protein 5 L homeolog antikoerper, F-box protein 5 S homeolog antikoerper, FBXO5 antikoerper, Fbxo5 antikoerper, fbxo5 antikoerper, fbxo5.L antikoerper, fbxo5.S antikoerper

Hintergrund:

Synonyms: F-box only protein 5, Early mitotic inhibitor 1, FBXO5, EMI1, FBX5

Background: FBXO5, also known as Emi1 (for early mitotic inhibitor), regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. Emi1 is required to arrest unfertilized eggs at metaphase of meiosis II and may be the long-sought mediator of CSF activity. Human Emi1 is similar to Xenopus laevis Emi1, which inhibits the APC (Cdc20) ubiquitination complex to allow accumulation of cyclin B.

Gen-ID: 26271

UniProt: Q9UKT4

Pathways: Mitotic G1-G1/S Phases