UACA Antikörper
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- Target Alle UACA Antikörper anzeigen
- UACA
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser UACA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
- Spezifität
- UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
- Kreuzreaktivität (Details)
- Human. Mouse.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Nuclei of myeloid leukemia biopsy cells
- Klon
- AE-5
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product UACA Primärantikörper
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- Applikationshinweise
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL),Optimal dilution for a specific application should be determined.
Positive_Control: HeLa or 293T cells. Highly expressed in skeletal muscle, heart, kidney and pancreas. Also expressed in epidermal melanocytes, eye muscles and thyroid follicular cells.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- UACA
- Andere Bezeichnung
- UACA (UACA Produkte)
- Synonyme
- NUCLING antikoerper, 2700059D02Rik antikoerper, nucling antikoerper, RGD1560011 antikoerper, uveal autoantigen with coiled-coil domains and ankyrin repeats antikoerper, UACA antikoerper, Uaca antikoerper
- Hintergrund
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Nuclear membrane binding protein, Uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA), NUCLING,UACA / Nucling (Nuclear Membrane Marker)
Cellular localisation: Nuclear membrane - Molekulargewicht
- 160kDa
- Gen-ID
- 55075, 108049
- Pathways
- Positive Regulation of Endopeptidase Activity
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