SERPINB3 Antikörper

Produktnummer ABIN6938379

Produktdetails anti-SERPINB3 Antikörper

Target: SERPINB3 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SERPINB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine proteases, such as neutrophil elastase. Serpins are family of serine protease inhibitors, contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant expression of serpin family members can contribute to a number of conditions, including emphysema (-1 antitrypsin deficiency), fatal bleeding (elastase to Thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). SCCA1 expression has been demonstrated to promote oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and its silencing in breast cancer cells has been shown to halt their proliferation.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human full-length SERPINB3 protein

Klon: CPTC-SERPINB3-2

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: U-2197, HaCaT, Squamous cells. Expressed in some hepatocellular carcinoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu SERPINB3

Target: SERPINB3 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3))

Andere Bezeichnung: SERPINB3 (SERPINB3 Produkte)

Synonyme: HsT1196 antikoerper, SCC antikoerper, SCCA-1 antikoerper, SCCA-PD antikoerper, SCCA1 antikoerper, T4-A antikoerper, LEUPIN antikoerper, PI11 antikoerper, SCCA-2 antikoerper, SCCA2 antikoerper, serpin family B member 3 antikoerper, serpin family B member 4 antikoerper, serpin B3 antikoerper, Somatic cell count antikoerper, SERPINB3 antikoerper, SERPINB4 antikoerper, Serpinb3 antikoerper, LOC483954 antikoerper, SCC antikoerper

Hintergrund: HsT1196, Protein T4 A, Protein T4-A, SCC, SCCA-PD, SCCA1, SCCAPD, Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 3, Serpin B3, SERPINB3, Squamous cell carcinoma antigen 1, T4 A, T4-A,Squamous Cell Carcinoma Antigen 1
Cellular localisation: Cytoplasm.

Molekulargewicht: 39kDa

Gen-ID: 6317, 227948

UniProt: P29508