Human Papilloma Virus 16 E1, E4 (HPV-16 E1, E4) (AA 36-41) Antikörper
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- Target
- Human Papilloma Virus 16 E1, E4 (HPV-16 E1, E4)
- Bindungsspezifität
- AA 36-41
- Reaktivität
- Human Papillomavirus 16 (HPV-16)
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Unkonjugiert
- Applikation
- Immunohistochemistry (IHC), Staining Methods (StM)
- Aufreinigung
- Purified by Protein A/G
- Immunogen
- Recombinant human HPV16 E1/E4 fragment (aa 36-41).
- Klon
- HPV16 E1-E4
- Isotyp
- IgG1 kappa
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anti-Human Papilloma Virus 16 E1, E4 (HPV-16 E1, E4) (AA 36-41) antibody
HPV-16 E1, E4 Reaktivität: Human Papillomavirus 16 (HPV-16) IHC, StM Wirt: Maus Monoclonal HPV16 E1-E4 unconjugated
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- Applikationshinweise
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Positive Control: HPV-16 infected cells. Cervical tissue.
Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1.0 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- 10 mM PBS without BSA and without Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- 4 °C,-80 °C
- Informationen zur Lagerung
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months.
- Haltbarkeit
- 24 months
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- Target
- Human Papilloma Virus 16 E1, E4 (HPV-16 E1, E4)
- Andere Bezeichnung
- HPV16 E1/E4 (Human Papilloma Virus 16)
- Substanzklasse
- Viral Protein
- Hintergrund
- The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a 'high-risk' sexually-transmitted HPV that can lead to cervical, anal, vulvar, head, neck, and penile cancer. The HPV16E1/E4 protein is expressed abundantly in cells supporting viral DNA amplification, but is lost during malignant progression. HPV16E1/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. HPV16E1/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle, and this association may increase the efficiency with which HPV16E1/E4 is able to prevent mitotic entry. HPV16E1/E4 also associates with keratin intermediate filaments and causes the network to collapse.
- Molekulargewicht
- 16kDa
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