FCGR2A Antikörper
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- Target Alle FCGR2A Antikörper anzeigen
- FCGR2A (Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser FCGR2A Antikörper ist unkonjugiert
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Applikation
- Immunofluorescence (IF), Flow Cytometry (FACS), Functional Studies (Func)
- Spezifität
- This MAb binds most strongly to the IIa isoforms of CD32 (FcRII), a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human FCGR2A protein
- Klon
- FCGR2A-479
- Isotyp
- IgG2b kappa
- Top Product
- Discover our top product FCGR2A Primärantikörper
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- Applikationshinweise
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Known_Application: Functional Studies (Order Ab without BSA & Azide), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: K-562 cells. Lymph node, tonsil and placenta.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- FCGR2A (Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A))
- Andere Bezeichnung
- FCGR2A (FCGR2A Produkte)
- Synonyme
- CD32 antikoerper, CD32A antikoerper, CDw32 antikoerper, FCG2 antikoerper, FCGR2 antikoerper, FCGR2A1 antikoerper, FcGR antikoerper, IGFR2 antikoerper, CD32a antikoerper, Fc fragment of IgG receptor IIa antikoerper, FCGR2A antikoerper
- Hintergrund
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CD32A, Fc fragment of IgG low affinity IIa receptor, Fc gamma RIIa, FCGR2A, FcgRII, IGFR2, IgG Fc receptor II-a, Low affinity immunoglobulin gamma Fc region receptor II-a, Ly-17, Ly-m20, LyM-1, Lymphocyte antigen 17,CD32 (Fc Gamma RIIa)
Cellular localisation: Cell Surface - Molekulargewicht
- 40kDa
- Gen-ID
- 2212, 352642
- UniProt
- P12318
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