VDAC1 Antikörper (AA 85-190)
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- Target Alle VDAC1 Antikörper anzeigen
- VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))
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Bindungsspezifität
- AA 85-190
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser VDAC1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Spezifität
- May detect VDAC2 due to sequence similarity
- Kreuzreaktivität
- Human, Ratte
- Homologie
- Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human VDAC1
- Isotyp
- IgG
- Top Product
- Discover our top product VDAC1 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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Penehyclidine hydrochloride prevents anoxia/reoxygenation injury and induces H9c2 cardiomyocyte apoptosis via a mitochondrial pathway." in: European journal of pharmacology, Vol. 797, pp. 115-123, (2017) (PubMed).
: "Resveratrol improves mitochondrial function in the remnant kidney from 5/6 nephrectomized rats." in: Acta histochemica, Vol. 119, Issue 4, pp. 392-399, (2017) (PubMed).
: "Penehyclidine hydrochloride post-conditioning reduces ischemia/reperfusion-induced cardiomyocyte apoptosis in rats." in: Experimental and therapeutic medicine, Vol. 14, Issue 5, pp. 4272-4278, (2017) (PubMed).
: "Proteomic identification of mitochondrial targets involved in andrographolide sodium bisulfite-induced nephrotoxicity in a rat model." in: Environmental toxicology and pharmacology, Vol. 40, Issue 2, pp. 592-9, (2015) (PubMed).
: "Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease." in: Human molecular genetics, Vol. 21, Issue 23, pp. 5131-46, (2012) (PubMed).
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Penehyclidine hydrochloride prevents anoxia/reoxygenation injury and induces H9c2 cardiomyocyte apoptosis via a mitochondrial pathway." in: European journal of pharmacology, Vol. 797, pp. 115-123, (2017) (PubMed).
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- Target
- VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))
- Andere Bezeichnung
- VDAC (VDAC1 Produkte)
- Synonyme
- vdac1 antikoerper, VDAC1 antikoerper, 5076 antikoerper, ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1 antikoerper, ATVDAC1 antikoerper, T22N4.9 antikoerper, T22N4_9 antikoerper, voltage dependent anion channel 1 antikoerper, PORIN antikoerper, VDAC-1 antikoerper, AL033343 antikoerper, Vdac5 antikoerper, fa13f11 antikoerper, wu:fa13f11 antikoerper, zgc:85830 antikoerper, voltage-dependent anion channel 1 S homeolog antikoerper, voltage-dependent anion channel 1 antikoerper, voltage dependent anion channel 1 antikoerper, vdac1.S antikoerper, vdac1 antikoerper, VDAC1 antikoerper, Vdac1 antikoerper
- Hintergrund
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Synonyms: PORIN, VDAC-1, Voltage-dependent anion-selective channel protein 1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, VDAC1, VDAC
Background: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules, in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
- Gen-ID
- 7416
- UniProt
- P21796
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