TRAP1 Antikörper (AA 501-650) (FITC)

Produktnummer ABIN686654

Produktdetails anti-TRAP1 Antikörper (FITC)

Target: TRAP1 (TNF Receptor-Associated Protein 1 (TRAP1))

Bindungsspezifität: AA 501-650

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRAP1 Antikörper ist konjugiert mit FITC

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HSP75

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-TRAP1 Antikörper (FITC) (ABIN686654)

Lettini, Sisinni, Condelli, Matassa, Simeon, Maddalena, Gemei, Lopes, Vita, Del Vecchio, Esposito, Landriscina: "TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1792-1803, (2016) (PubMed).

Details zu TRAP1

Target: TRAP1 (TNF Receptor-Associated Protein 1 (TRAP1))

Andere Bezeichnung: Hsp75/Trap1 (TRAP1 Produkte)

Synonyme: HSP 75 antikoerper, HSP75 antikoerper, HSP90L antikoerper, TRAP-1 antikoerper, 2410002K23Rik antikoerper, fc85a11 antikoerper, wu:fc85a11 antikoerper, TNF receptor associated protein 1 antikoerper, TNF receptor-associated protein 1 antikoerper, TRAP1 antikoerper, Trap1 antikoerper, trap1 antikoerper

Hintergrund:

Synonyms: HSP75, HSP 75, HSP90L, TRAP-1, Heat shock protein 75 kDa, mitochondrial, TNFR-associated protein 1, Tumor necrosis factor type 1 receptor-associated protein, TRAP1

Background: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.

Gen-ID: 10131

UniProt: Q12931