Angiotensin II Type 2 Receptor Antikörper (HRP)

Produktnummer ABIN668625

Produktdetails anti-Angiotensin II Type 2 Receptor Antikörper (HRP)

Target: Angiotensin II Type 2 Receptor (AGTR2) (Angiotensin II Receptor, Type 2 (AGTR2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Angiotensin II Type 2 Receptor Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Kaninchen, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse AT2R1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Gentamicin sulfate

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Angiotensin II Type 2 Receptor

Target: Angiotensin II Type 2 Receptor (AGTR2) (Angiotensin II Receptor, Type 2 (AGTR2))

Andere Bezeichnung: AT2R (AGTR2 Produkte)

Synonyme: AT2 antikoerper, ATGR2 antikoerper, MRX88 antikoerper, AI316812 antikoerper, AW107640 antikoerper, AT2-R antikoerper, AT2R antikoerper, AT₂R antikoerper, at2 antikoerper, zgc:113016 antikoerper, AGTR2 antikoerper, angiotensin II receptor type 2 antikoerper, angiotensin II receptor, type 2 antikoerper, AGTR2 antikoerper, Agtr2 antikoerper, agtr2 antikoerper

Hintergrund:

Synonyms: AG2S, Agtr 1, Agtr1, AGTR1_HUMAN, Agtr1a, AGTR1B, Ang II, Angiotensin II receptor type 1, Angiotensin II type 1 receptor, Angiotensin II type-1 receptor, Angiotensin receptor 1, Angiotensin receptor 1B, AT 1B, AT 1r, AT-1B, AT-1r, AT1, At1a, AT1AR, AT1B, AT1BR, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R, Type 1 angiotensin II receptor, Type 1B angiotensin II receptor, Type-1 angiotensin II receptor.

Background: Angiotensin II (Ang II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 and AT2, most of the major cardiovascular effects seem to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins and induction of others. PLC?is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event. Ang II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases, and induces MKP-1, indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by coimmunoprecipitation. The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases and has several putative phosphorylation sites.

Molekulargewicht: 41kDa

Gen-ID: 11607

Pathways: ACE Inhibitor Pathway, Hormone Transport, Regulation of Systemic Arterial Blood Pressure by Hormones