GABRG2 Antikörper (Cytoplasmic Loop)

Produktnummer ABIN6658227

Produktdetails anti-GABRG2 Antikörper

Target: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Bindungsspezifität: Cytoplasmic Loop

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Kreuzreaktivität: Maus, Ratte (Rattus)

Aufreinigung: Anti-GABA(A) Receptor gamma 2 Antibody is directed against rat GABA(A) Receptor gamma 2. The antibody was affinity purified from monospecific antiserum by immune affinity purification. Reactivity is expected from the following species based on 100% sequence homology: bovine, chicken, canine, human, mouse, and non-human primate.

Immunogen:

Immunogen: Anti-GABA(A) Receptor gamma 2 Antibody was produced by repeated immunizations with recombinant fusion proteins from the cytoplasmic loop of the gamma 2 subunit.

Immunogen Type: Recombinant Protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry Dilution: 1:100

Application Note: Anti-GABA(A) Receptor gamma 2 (Rabbit) antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of 46 kDa in size corresponding to the gamma 2 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.

Western Blot Dilution: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Details zu GABRG2

Target: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Andere Bezeichnung: GABA(A) Receptor gamma 2 (GABRG2 Produkte)

Synonyme: cae2 antikoerper, eca2 antikoerper, gabrg1 antikoerper, gefsp3 antikoerper, si:ch211-145n14.1 antikoerper, CAE2 antikoerper, ECA2 antikoerper, GEFSP3 antikoerper, GABAA-R antikoerper, Gabrg-2 antikoerper, gamma2 antikoerper, gamma-aminobutyric acid type A receptor gamma2 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, gamma 2 antikoerper, gamma-aminobutyric acid type A receptor gamma 2 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 antikoerper, GABRG2 antikoerper, gabrg2 antikoerper, Gabrg2 antikoerper

Hintergrund:

Synonyms: Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2

Background: Anti-GABA(A) Receptor gamma 2 Antibody detects GABA(A) Receptor gamma 2. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Anti-GABA(A) Receptor gamma 2 Antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRG2

Gen-ID: 29709

NCBI Accession: NP_899156

UniProt: P18508